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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T14988 | CMPD1 | MAPK | |
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM). | |||
T16501 | PF-3644022 | p38 MAPK , Serine Protease , MAPK | |
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib... | |||
T12058 | MK2-IN-3 hydrate | MK-2 Inhibitor III | ERK , MAPK , MNK |
MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM) | |||
T9034 | MK2-IN-3 | MK2 Inhibitor III | MAPK |
MK2-IN-3 (MK2 Inhibitor III) is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis | |||
T15250 | ETC-206 | MNK | |
ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM). | |||
T4442 | MK2-IN-1 hydrochloride | MK2 Inhibitor,MK 25 | MAPK |
MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 μM) [1]. | |||
T6152 | PD318088 | MEK | |
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. | |||
T3468 | Tomivosertib | eFT508 | MNK , PD-1/PD-L1 |
Tomivosertib (eFT508) is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM. | |||
T6785 | BI-847325 | Apoptosis , MEK , Aurora Kinase | |
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. | |||
T21980 | PD 198306 | MEK | |
PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1. | |||
T80062 | Mitogen-activated protein kinase 1 | MAPK1 | NF-κB |
Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases. Its catalytic action phosphorylates substrate proteins, serving as a regulatory s... | |||
T6692 | TAK-733 | TAK733,TAK 733 | MEK |
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. | |||
T2708 | SL327 | SL 327,SL-327 | MEK , DNA/RNA Synthesis |
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier. | |||
T21635 | PD184161 | MEK | |
PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1]. | |||
T21295 | BIX02189 | BIX 02189 | ERK , MEK |
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM). | |||
T4424 | SLV-2436 | SEL-201,SLV 2436,SEL201-88 | MNK |
SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM). | |||
T2378 | RGB-286638 free base | GSK-3 , MEK , JAK , CDK | |
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a... | |||
T6440 | CGP 57380 | MNK1 Inhibitor | Apoptosis , MNK |
CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. | |||
T2443 | CI-1040 | PD 184352 | Apoptosis , MEK |
CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM). | |||
T2623 | PD98059 | PD 98059 | ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy |
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy. | |||
T7610 | GW284543 | UNC10225170 | MEK |
GW284543 (UNC10225170) is a selective inhibitor of MEK5 . | |||
T6189 | Mirdametinib | PD325901,PD0325901 | Apoptosis , MEK , Autophagy |
Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by inhibiting p-ERK1/2 expression and inducing apoptosis. | |||
T5412 | RO4987655 | CH4987655,RG7167 | MEK |
RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2). | |||
T6971 | Ro 5126766 | CH5126766,Avutometinib,VS-6766,RO5126766 | Raf , MEK |
RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1. | |||
T1144L | Lidocaine Hydrochloride hydrate | EGFR , Sodium Channel | |
Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property. | |||
T6218 | Selumetinib | ARRY-142886,AZD6244 | Apoptosis , ERK , MEK |
Selumetinib (AZD6244) (AZD6244) is an effective, specific inhibitor of MEK1 and ERK1/2 phosphorylation (IC50: 14/10 nM). | |||
T6760 | APS-2-79 hydrochloride | APS-2-79 HCl,APS-2-79 | MEK , MAPK |
APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activ... | |||
T0468 | Lidocaine | Lignocaine,Alphacaine,Xylocaine | Apoptosis , ERK , NF-κB , MEK , Sodium Channel , Histamine Receptor |
Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammat... | |||
T6223 | U0126-EtOH | U0126 Ethanol,U0126 | Mitophagy , Influenza Virus , MEK , Autophagy |
U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM). | |||
T6083 | AZD8330 | ARRY-424704,ARRY-704 | ERK , MEK |
AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. | |||
T7196 | HG-10-102-01 | LRRK2 | |
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM). | |||
T2508 | Binimetinib | ARRY-438162,ARRY-162,MEK162 | MEK , Autophagy |
Binimetinib (ARRY-162) (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/2 (IC50: 12 nM) in a cell-free assay. | |||
T2125 | Trametinib | GSK1120212,JTP-74057 | Apoptosis , MEK , Autophagy |
Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis. | |||
T3623 | Cobimetinib | RG7420,XL518,GDC-0973 | Apoptosis , MEK |
Cobimetinib (GDC-0973) is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of e... | |||
T6131 | Pimasertib | AS703026,MSC1936369B,SAR 245509 | MEK |
Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. | |||
T6636 | Refametinib | BAY 86-97661,BAY 869766,RDEA119 | MEK |
Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM). | |||
T6843 | GDC-0623 | G-868,GDC0623,RG 7421,MEK inhibitor 1 | Apoptosis , MEK |
GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. | |||
T1144 | Lidocaine hydrochloride | Lidocaine HCL,Lignocaine hydrochloride,Xyloneural,Lidothesin | Apoptosis , ERK , NF-κB , MEK , Sodium Channel |
Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its ... | |||
T5857 | Trametinib (DMSO solvate) | Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate) | Apoptosis , MEK |
Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM) | |||
T9321 | Zapnometinib | ATR-002,3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid,PD0184264,2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid | Influenza Virus , MEK , Antibacterial |
Zapnometinib (ATR-002) is a MEK inhibitor. | |||
T21332 | U0126 | U 0126,U-0126 | Mitophagy , MEK , Autophagy |
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhibits autophagy and mitophagy. | |||
T22677 | Cobimetinib racemate | Cobimetinib (racemate) | MEK |
Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated protein kinase, is a key component of the RAS/RAF/MEK/ERK pathwa... | |||
T6130 | Skepinone-L | CBS3830 | p38 MAPK , Autophagy |
Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor. | |||
T68139 | Scio-323 | p38 MAPK | |
Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor. | |||
T7667 | R1487 | p38 MAPK | |
R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor. | |||
T29071 | UR13870 | Org 48762-0,POLB 001,UR-13870,UR 13870 | p38 MAPK |
UR-13870 (Org 48762-0) is an orally active and selective inhibitor of p38 mitogen-activated protein kinase (MAPK), which prevents bone damage in collagen-induced arthritis in mice. | |||
T6789 | BMS582949 | BMS 582949,PS540446,BMS-582949 | p38 MAPK |
BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13 nM, inhibiting both p38 kinase activity and activation of p38. | |||
T67830 | P38α inhibitor 3 | p38 MAPK | |
p38α inhibitor 3 is a inhibitor of the mitogen-activated protein kinase p38α that can block the effectiveness of myoblast differentiation. | |||
T6047 | Ralimetinib dimesylate | LY2228820 dimesylate,Ralimetinib,LY2228820,Ralimetinib Mesylate | Apoptosis , p38 MAPK , Autophagy |
Ralimetinib dimesylate (LY2228820 dimesylate) is the dimesylate salt form of LY2228820, a tri-substituted imidazole derivative and orally available, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential an... | |||
TP1430 | DTP3 TFA (1809784-29-9 free base) | DTP3 TFA | Others |
DTP3 TFA (1809784-29-9 free base) (DTP3 TFA) is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TMS2181 | Trans-Zeatin | (E)-Zeatin | ERK , MEK , Endogenous Metabolite |
trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. | |||
T2836 | Isorhamnetin | 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin | MEK , PI3K , Endogenous Metabolite |
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD... | |||
T7030 | Anemarsaponin B | p38 MAPK , NF-κB , MEK , COX , NO Synthase | |
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c... | |||
T3908 | 10-Gingerol | Apoptosis | |
10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, p38 MAPK (p38), c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK). | |||
T3892 | Isoacteoside | Isoverbascoside | NF-κB |
Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B p... | |||
TWS1977 | Kamebakaurin | Kamebakaurine | NF-κB |
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression... | |||
T3816 | Velutin | NF-κB , HIF/HIF Prolyl-Hydroxylase | |
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ... | |||
TN1410 | Asperulosidic acid | ASPA | ERK , NF-κB |
Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-a... | |||
TN1448 | (-)-Bornyl acetate | L-(-)-Bornyl acetate,Bornyl acetate | p38 MAPK , NF-κB , JNK , Antifungal |
(-)-Bornyl acetate (L-(-)-Bornyl acetate) is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal activity. (-)-Bornyl acetate shows highly active whitening... | |||
T5S0581 | Sec-O-Glucosylhamaudol | Hamaudol 3-glucoside | Others , Opioid Receptor |
Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) has anti-inflammatory effect through regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-stimulated RAW264.7 cell line. Intrathecal Sec-O-Glucosylhamaudo... | |||
T3877 | Esculentoside A | NF-κB , COX | |
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmun... | |||
T6S1369 | Vitexin | Apigenin-8-C-glucoside | Antioxidant |
1. Vitexin has antinociceptive and antispasmodic activities. 2. Vitexin exhibits a prominent first-pass effect. 3. Vitexin has antioxidant, antimyeloperoxidase, and α-glucosidase inhibitory activities. 4. Vitexin can eit... | |||
T6429 | Caffeic Acid Phenethyl Ester | Phenylethyl Caffeate,CAPE | Apoptosis , NF-κB |
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective... | |||
T5S0754 | Isoquercetin | 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside | NF-κB , Wnt/beta-catenin , NO Synthase |
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in ... | |||
T1719 | Bufalin | ATPase | |
Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potenti... | |||
T6S1684 | 8-Gingerol | Antioxidant , Antibacterial , TRP/TRPV Channel | |
1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic... | |||
TN4986 | Selinidin | IκB/IKK , p38 MAPK , TNF | |
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation. | |||
TMA1012 | Ganoderiol F | Androgen Receptor , HIV Protease , Autophagy | |
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM. It induced... | |||
TN4635 | Neoechinulin A | NADPH-oxidase , Beta Amyloid , ASK , IκB/IKK , p38 MAPK , TNF , NOS , NF-κB , COX , Prostaglandin Receptor | |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) ... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-04572 | MKK4 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is... | |||
TMPY-04756 | MEK1 Protein, Mouse, Recombinant | Mouse | Baculovirus-Insect Cells |
MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin... | |||
TMPY-04569 | MEK1 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin... | |||
TMPY-04412 | Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein,... | |||
TMPY-04425 | PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated... | |||
TMPY-04410 | MAP4K5 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Mitogen-activated protein kinase kinase kinase kinase 5, also known as Kinase homologous to SPS1/STE2, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, and MAP4K5, is a cytoplasm protein that belongs to the protein ... | |||
TMPY-04378 | MAPKAPK3 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases ... | |||
TMPY-04364 | MKK6 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ... | |||
TMPY-04749 | MKK6 Protein, Human, Recombinant (S207D, T211D) | Human | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ... | |||
TMPY-04389 | MAP3K8 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that ... | |||
TMPY-04365 | MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST) | Human | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ... | |||
TMPY-04748 | MKK6 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ... | |||
TMPY-04551 | P38 delta/MAPK13 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
The p38 family of mitogen-activated protein kinases (MAPK) includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms tha... | |||
TMPJ-01378 | Mp1 Protein, Human, Recombinant (His) | Human | E. coli |
Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding pro... | |||
TMPY-04531 | P38 delta/MAPK13 Protein, Human, Recombinant (GST), Activated in vitro | Human | Baculovirus-Insect Cells |
The p38 family of mitogen-activated protein kinases (MAPK) includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms tha... | |||
TMPY-04544 | MEK2 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/... | |||
TMPY-04554 | JNK1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellula... | |||
TMPY-04550 | JNK2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environm... | |||
TMPY-04571 | ERK2 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, diffe... | |||
TMPY-04430 | P38 gamma/MAPK12 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/t... | |||
TMPY-04429 | P38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/t... | |||
TMPY-04260 | P38 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as prol... | |||
TMPY-04539 | ERK2 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, diffe... | |||
TMPY-05004 | FGF-4 Protein, Human, Recombinant | Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specificati... | |||
TMPY-02028 | RON/CD136 Protein, Human, Recombinant (His) | Human | HEK293 |
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. ... | |||
TMPY-02361 | VEGFR2/KDR Protein, Human, Recombinant (His) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-02087 | IL-24 Protein, Human, Recombinant (His) | Human | HEK293 |
Interleukin-24 (IL-24) also known as Melanoma differentiation-associated gene 7 protein (MDA-7) is a member of the IL10 family of cytokines. IL-24/MDA-7/IL24 can induce apoptosis selectively in various cancer cells. Over... | |||
TMPK-00696 | PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II) | Human | Baculovirus-Insect Cells |
The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-... | |||
TMPY-02595 | DUSP14 Protein, Human, Recombinant (His & MBP) | Human | E. coli |
Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosph... | |||
TMPJ-00791 | HER2/ERBB2 Protein, Rat, Recombinant (E. coli, His) | Rat | E. coli |
ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpr... | |||
TMPJ-01300 | PDCD10 Protein, Human, Recombinant | Human | E. coli |
Programmed Cell Death Protein 10 (PDCD10) belongs to the PDCD10 family. PDCD10 exists as a homodimer and is widely expressed. PDCD10 can increase mitogen-activated protein kinase activity and MST4 activity. PDCD10 is req... | |||
TMPY-04547 | PBK/TOPK Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara... | |||
TMPY-04407 | LOK Protein, Human, Recombinant (His) | Human | E. coli |
Serine / threonine-protein kinase 1, also known as Lymphocyte-oriented kinase, STK1 and LOK, belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE2 subfamily. Protein kinases constitute a... | |||
TMPJ-00886 | ATF1 Protein, Human, Recombinant (His) | Human | E. coli |
Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by r... | |||
TMPY-02519 | BLVRB Protein, Human, Recombinant (His) | Human | E. coli |
Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann... | |||
TMPJ-00996 | VHR Protein, Human, Recombinant (His) | Human | E. coli |
Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues... | |||
TMPY-02964 | Calcineurin B/PPP3R1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
PPP3R1 belongs to the calcineurin regulatory subunit family. It is a regulatory subunit of calcineurin. Calcineurin is composed of two subunits: calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nucle... | |||
TMPY-04143 | Chemerin/RARRES2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Retinoic acid receptor responder protein 2 (RARRES2) is a small secreted protein involved in multiple cancers, including adrenocortical carcinoma (ACC). Serum RARRES2 may be used as a novel prognostic marker for ACC. Ret... | |||
TMPY-02172 | Midkine Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, h... | |||
TMPY-00367 | Chemerin/RARRES2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Retinoic acid receptor responder protein 2 (RARRES2) is a small secreted protein involved in multiple cancers, including adrenocortical carcinoma (ACC). Serum RARRES2 may be used as a novel prognostic marker for ACC. Ret... | |||
TMPY-04530 | VEGFR2/KDR Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-03202 | VEGFR2/KDR Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-02678 | VEGFR2/KDR Protein, Rat, Recombinant (His) | Rat | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-01044 | VEGFR2/KDR Protein, Human, Recombinant (hFc) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-05657 | VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-04794 | VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-04795 | VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-02127 | DUSP3 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Vaccinia H1-related phosphatase (VHR) is classified as a dual-specificity phosphatase (DUSP), and the other name is dual-specificity phosphatase 3 (DUSP3). DUSPs are a heterogeneous group of protein phosphatases that can... | |||
TMPY-03482 | DUSP3 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
Vaccinia H1-related phosphatase (VHR) is classified as a dual-specificity phosphatase (DUSP), and the other name is dual-specificity phosphatase 3 (DUSP3). DUSPs are a heterogeneous group of protein phosphatases that can... | |||
TMPY-05382 | VEGFR2/KDR Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
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カタログ番号 | 製品名 | ||
---|---|---|---|
L1400 | MAPK Inhibitor Library | 365 compounds | |
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases; |